[Cold-adapted strain of A/Leningrad/134/47/57 (H2N2)--a special attenuation donor of live influenza vaccine for children and the isolation of its recombinants].
Identifieur interne : 002E36 ( Main/Exploration ); précédent : 002E35; suivant : 002E37[Cold-adapted strain of A/Leningrad/134/47/57 (H2N2)--a special attenuation donor of live influenza vaccine for children and the isolation of its recombinants].
Auteurs : L M Garmashova ; F I Polezhaev ; G I AleksandrovaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adaptation physiologique, Animaux, Antigènes viraux (immunologie), Basse température, Enfant, Humains, Recombinaison génétique, Réplication virale, Souris, Sous-type H2N2 du virus de la grippe A, Température, Vaccins antigrippaux (immunologie), Vaccins antigrippaux (isolement et purification), Vaccins atténués (immunologie), Vaccins atténués (isolement et purification), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification).
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Antigènes viraux, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- isolement et purification : Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A.
- Adaptation physiologique, Animaux, Basse température, Enfant, Humains, Recombinaison génétique, Réplication virale, Souris, Sous-type H2N2 du virus de la grippe A, Température.
English descriptors
- KwdEn :
- Adaptation, Physiological, Animals, Antigens, Viral (immunology), Child, Cold Temperature, Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza Vaccines (immunology), Influenza Vaccines (isolation & purification), Mice, Recombination, Genetic, Temperature, Vaccines, Attenuated (immunology), Vaccines, Attenuated (isolation & purification), Virus Replication.
- MESH :
- chemical , immunology : Antigens, Viral, Influenza Vaccines, Vaccines, Attenuated.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- isolation & purification : Influenza A virus, Influenza Vaccines, Vaccines, Attenuated.
- Adaptation, Physiological, Animals, Child, Cold Temperature, Humans, Influenza A Virus, H2N2 Subtype, Mice, Recombination, Genetic, Temperature, Virus Replication.
Abstract
A cold-adapted A/Leningrad/134/47/57 (H2N2) strain, a special donor of attenuation for generation of recombinant vaccine strains safe for children, has been developed and characterized. The genetic markers of this virus (temperature sensitivity of the cold-adapted strain, temperature optimum of the neuraminidase activity) were compared with those of A/Leningrad/134/17/57 (H2N2) strain, a donor of attenuation for a live influenza vaccine for adults. The A/Leningrad/134/47/57 (H2N2) strain was found to have a more marked temperature sensitivity and cold adaptation which correlated with the presence in its genome of multiple temperature-sensitive mutations in genes 1, 2, 5, 7, and 8. When the cold-adapted A/Leningrad/134/47/57 (H2N2) strain was hybridized with epidemic A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) strains, recombinants were isolated which are candidate vaccine strains for a live influenza vaccine for children. The recombinants inherited the antigenic specificity of the current viruses and the temperature specificity and cold-adaptation of the donor of attenuation, A/Leningrad/134/47/57 (H2N2).
PubMed: 6710978
Affiliations:
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Le document en format XML
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M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name></author><author><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name></author><author><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological</term><term>Animals</term><term>Antigens, Viral (immunology)</term><term>Child</term><term>Cold Temperature</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (isolation & purification)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (isolation & purification)</term><term>Mice</term><term>Recombination, Genetic</term><term>Temperature</term><term>Vaccines, Attenuated (immunology)</term><term>Vaccines, Attenuated (isolation & purification)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique</term><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Basse température</term><term>Enfant</term><term>Humains</term><term>Recombinaison génétique</term><term>Réplication virale</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Température</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (isolement et purification)</term><term>Vaccins atténués (immunologie)</term><term>Vaccins atténués (isolement et purification)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Vaccins atténués</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Physiological</term><term>Animals</term><term>Child</term><term>Cold Temperature</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Mice</term><term>Recombination, Genetic</term><term>Temperature</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term><term>Animaux</term><term>Basse température</term><term>Enfant</term><term>Humains</term><term>Recombinaison génétique</term><term>Réplication virale</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A cold-adapted A/Leningrad/134/47/57 (H2N2) strain, a special donor of attenuation for generation of recombinant vaccine strains safe for children, has been developed and characterized. The genetic markers of this virus (temperature sensitivity of the cold-adapted strain, temperature optimum of the neuraminidase activity) were compared with those of A/Leningrad/134/17/57 (H2N2) strain, a donor of attenuation for a live influenza vaccine for adults. The A/Leningrad/134/47/57 (H2N2) strain was found to have a more marked temperature sensitivity and cold adaptation which correlated with the presence in its genome of multiple temperature-sensitive mutations in genes 1, 2, 5, 7, and 8. When the cold-adapted A/Leningrad/134/47/57 (H2N2) strain was hybridized with epidemic A/Brazil/11/78 (H1N1) and A/Bangkok/1/79 (H3N2) strains, recombinants were isolated which are candidate vaccine strains for a live influenza vaccine for children. The recombinants inherited the antigenic specificity of the current viruses and the temperature specificity and cold-adaptation of the donor of attenuation, A/Leningrad/134/47/57 (H2N2).</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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